Two simple, rapid and sensitive spectrophotometric methods were proposed for determination of bisacodyl in pure and in tablet forms. The method I depended on reaction of drug and tetracyanoethylene by charge transfer complex with maximum absorbance at 398 nm.Beer’s law was obeyed in the range 0.05-0.3 µgml -1 . Method II based on bromination-oxidation reaction using bromate-bromide mixture with thymol blue and methyl orange as reagents and measuring the absorbance of the unbleached dye at 545 nm and 510 nm. Beer’s law was obeyed in the range4-24 µgml -1 and 4-10 µgml -1 . Under optimized conditions, the experimental conditions were optimized and Beer's law was obeyed over the applicable concentration ranges. The methods were applied successfully to the tablets containing bisacodyl. The results obtained are in good agreement with those obtained using official and reference methods.

The efficacy of six species of Elaeocarpus found in the Western ghats belt of Karnataka namely, E. munronii, E. serratusvar. serratus, E. serratus var. wiebelii, E. tuberculatus, E. variabilisand Elaeocarpus sp. (unidentified) was studied for their antimicrobial activity against five clinically important bacterial and four phytofungal pathogens using Disc diffusion method and Poisoned food technique. All the speciesof Elaeocarpus showed varying degrees of antimicrobial activity in 50% aqueous extracts. Extracts of E. tuberculatus and E. variabilis inhibited all the pathogens except E. coli and R. solani. E. serratus var. serratus and E. serratus var. weibelii were found to be more effective against bacterial pathogens than fungal pathogens. Phytochemical analysis of aqueous leaf extracts of six Elaeocarpus species was also carried out.

Oxadiazoles are an important class of bioactive andindustrially important organic compounds. Steroids and non-steroidal antiinflammatory drugs are globally used for reducing inflammation in the body. 1,3,4-Oxadiazoles are five membered heterocyclic compounds, containing one oxygen and two nitrogen atoms. Literature indicates that compounds containing this nucleus have wide range of pharmacological activities include anti-inflammatory, antimicrobial, analgesic, anti-HIV, antiparkinsonian, antiproliferative, anticonvulsant, antimalarial, antihypertensive, antioxidant, antitubercular, sedativehypnotic, hypoglycemic etc. Oxadiazoles are also used as photosenstizers, lipid peroxidation inhibitor, genotoxic, spasmolytic, diuretic, antiemetic, hypnotic, sedative, hypotensive, hypoglycemic, nematocidal, amoebicidal agents and plays an important role in agricultural chemistry. Researchers have designed a variety of novel compounds with a means of preventing or minimizing the adverse effects of drugs which cause some serious gastric problems, and risks of complications regarding potential cardiovascular hazards of cyclooxygenase inhibitors. The review represents a broad view on the analgesic and anti-inflammatory activity possessed by compounds having 1,3,4-oxadiazole nucleus.

In the present work, eight novel 3-[4-(1-Acetyl-5-(3,4-Disubstituted Phenyl)-4,5-Dihydro-1h-Pyrazol-3-Yl) Phenyl]-2-Substutied Phenyl Quinolin-4(3H)-One Derivatives [4a-h] were synthesized by condensation between substituted quinazolinones and hydrazine hydrate in the presence of glacial acetic acid. The structures of the synthesized compounds were characterized on the basis of IR, 1HNMR and Mass spectral data. All the synthesized compounds are screened for their anti-inflammatory activity by paw edema method, Indomethacin is employed as a reference standard. From the results it is concluded that, compounds 4b, 4e, 4f, 4g exhibited potent, rest of compounds exhibited moderate anti-inflammatory activity.

Recently great attention has been diverted towards cyclic and acyclic nitrogen containing heterocyclic compounds in pharmaceuticals as well as for medicinal purposes. In the present work the desired substituted 3, 4- dihydropyrimidin-2 (1H) - one (DHPM) derivatives were synthesized by treating substituted aromatic aldehydes, urea and ethyl acetoacetate in (1:1:1) mole ratio in presence of Gold nano particles (AuNPs) having size of 15 nm as a catalyst. The structures of newly synthesized derivatives have been established on the basis of their melting points, FT-IR, and 1 HNMR spectral analysis. All newly synthesized 3, 4-dihydropyrimidin-2 (1H) - one (DHPM) derivatives were tested for their antibacterial activities using cup plate method by measuring inhibition zone. The B-3 derivative showed more potent antibacterial activity than standard drug Streptomycin.