New 4-methyl-1-nitroacridine analogues with tuftsin/retro-tuftsin derivatives were developed as potential anticancer agents. The cytotoxic activity of the novel obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab) melanoma cell line and neuroblastoma SH-SY5Y. Among the investigated derivatives only compound (8) was cytotoxic against amelanotic Ab melanoma and DC form of SH-SY5Y neuroblastoma after 72hrs incubation with IC50 values 88 and 116 µM, respectively.

India is a botanical garden of the world having rich natural resources. Momordica charantiais a herbal, slender, tendril climbing, annual vine grown in tropical and subtropical regions. It is a consuming and medicinal plant. It is known as bitter melon or gourd. It possesses properties like- anticancer, antidiabetic, anti-inflammatory, antimicrobial, antioxidant, antiulcer etc. It consists alkaloids, charantin, flavonoids, glycosides, phenolics, tannins, terpenoids etc. Momordica charantia is rich in momordicin, momordin, kuguacin etc. In this article there is a brief description including varieties, bioactive composition etc regarding Momordica charantia commonly known as Karela.

This manuscript aims to illustrate the impurities stimulated during preparation of Propan-2-yl (2S) -2-{[(S)- (pentafluorophenoxy) (phenoxy) phosphoryl] amino} propanoate (compound 2) and their impact on active pharmaceutical ingredient (1).

The profound use of Khaya Senegalensis oil (K. S) and Azadirachta indica oil (A. I) in Northern Nigeria herbal medicine practice and the promising result outcome have marked these plants oils as those whose curative potentials may be harnessed in the manufacturing of useful drugs that can be viable alternatives to some of the present day antibiotics. The aim of this study was to evaluate the antimicrobial properties of Khaya Senegalensis oil and Azadirachta indica oil. Both oils were obtained from Uba central market of Borno State and tested for antimicrobial activities using serial dilution and agar well dilution using Levofloxacin as the standard. The activity index of the oil was also determined. Result showed that A. indica oil demonstrated a lower activity than K. senegalensis oil on Klebsella pneumoniae, Staph aureus and E. coli. However, synergistic study showed that the extracts when combined give a higher antimicrobial activity than the crude extracts alone.

This study was aimed at evaluation of the effect of ethanol leaf extract of Senna siamea on the central and peripheral nervous systems through analgesic and anti-inflammatory studies using laboratory animals. Fresh leaves of Senna siamea were collected, air-dried, pulverized and extracted using maceration with 95 % methanol and yielded 12.60 %. w/w after being concentrated. The extract was screened for phytochemical constituents using standard methods. The phytochemical studies of the methanol leaf extract of Senna siamea showed the presence some secondary metabolites such as alkaloids, flavonoids, cardiac glycosides, tannins, saponins, and terpenoids. The analgesic effect of the methanol leaf extract was evaluated with acetic acid induced writhing and thermally induced nociception for pain while the anti-inflammatory effect was evaluated using albumin-induced rat paw oedema model. The LD50 of the leaf extract was 3807 mg/kg. The methanol leaf extract of Senna siamea produced an inhibition on the writhing response induced by acetic acid as well as increased the time of tail flicking in a dose dependent manner. The leaf extract also significantly (P < 0.05) inhibited the inflammation induced by egg albumin in the rats paw. This study revealed that the methanol leaf extract of Senna siamea had effect on the central nervous systems through analgesic and anti-inflammatory analysis. Thus, it has scientifically justified the local use of the plant for the management and treatment of pain and inflammation.