This document provides a comprehensive review of Forensic Toxicology, emphasizing its role in legal investigations and healthcare. It highlights the multidimensional aspects of toxicology, including detection of drugs, poisons and alcohol in biological samples, interpretation of results, and the importance of analytical techniques. The paper reviews the principles of toxicokinetics and toxicodynamics, discusses challenges in sample collection and examines the legal and ethical considerations of toxicological analysis. Additionally, it addresses emerging technologies and the future scope of forensic toxicology in improving criminal investigations and public safety.

Combinatorial chemistry is an advanced and efficient technique that enables the rapid and economical synthesis of a large number of compounds within a short period. It plays a crucial role in modern drug discovery by reducing the time and cost of developing new and effective drugs. The field involves various techniques such as solid-phase synthesis, parallel synthesis, mixed (split-and-mix) synthesis and solution-phase synthesis, which are used to create diverse chemical libraries for screening potential drug candidates. This approach increases the chances of identifying new lead molecules and has become a vital part of medicinal chemistry. Overall, combinatorial chemistry significantly accelerates drug development and enhances competition in the pharmaceutical market.