The global peptide therapeutics market is undergoing a seismic shift, characterized by increasing demand for off-label and non-FDA and FDA approved peptides. While therapeutic peptides have established their position in the treatment of diseases like cancer, metabolic disorders and infectious diseases, the growing "peptide craze" is simultaneously being fueled by underground markets, fitness communities and direct-to-consumer platforms. This surge raises regulatory and safety concerns even as it pushes the industry toward innovation in synthesis technologies and sustainable practices. Technologies such as Resonant Acoustic Mixing (RAM), Inversion Mixing Technology Synthesizers (IMTS), Spin Rotating Technology Synthesizers (SRTS) and Shaking Technology Synthesizers (STS) are at the forefront of this transformation, significantly reducing environmental impact, process mass intensity (PMI) and hazardous solvent usage. This manuscript provides a comprehensive overview of the unregulated rise in peptide use alongside a scientific assessment of advanced and sustainable peptide synthesis technologies1-10.
